Antacid ranitidine could cause cancer, health alert sounded

The Drugs Controller of India on Tuesday sounded a public health alert on ranitidine, a old, cheaply-priced medicine used commonly to counter stomach acidity, as some drug regulators in other countries have found it to contain a chemical compound which can cause cancer. Drugs Controller, V.G. Somani, who is under the Directorate General of Health Services, has issued a directive to all states alerting them on ranitidine and asking them to ask all drug manufacturers to take measures to ensure patient safety. According to the directive, ranitidine medicines contain a nitrosamine impurity called N-nitrosodimethylamine (NDMA) at low levels. NDMA has been classified by International Agency for Research on Cancer (IARC) as probably carcinogenic to humans. Ranitidine is used for multiple indications in the country and is available in different formulations including tablets and injections. It is a prescription drug under Schedule H. The state drug controllers have been asked to communicate the manufacturers of ranitidine to verify their products and take appropriate action for public safety

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