Date: 12-May-2020

Dyno Therapeutics Announces Ocular Collaboration With Novartis To Develop Improved Gene Therapies With AAV Vectors Based On AI Technology

Dyno Therapeutics, a biotechnology company applying artificial intelligence (AI) to gene therapy, today announced a collaboration with Novartis to develop improved Adeno-Associated Virus (AAV) vectors for research, development, and commercialization of gene therapies for ocular diseases. The partnership will allow the parties to utilize Dyno’s CapsidMap™ artificial intelligence platform along with Novartis expertise in gene therapy development and global commercialization to deliver innovative gene therapies to patients with serious diseases of the eye.

“We are delighted to be collaborating with Novartis,” stated Eric D. Kelsic, Ph.D., CEO and Co‑founder of Dyno Therapeutics. “Many eye diseases are ideally suited to being treated with gene therapies, and more opportunities can be opened with new and improved AAV vectors. With their extensive ophthalmologic expertise, Novartis is an ideal partner to leverage Dyno’s platform to design AI-powered vectors to expand the impact of gene therapies for ocular diseases. This collaboration is a major step forward in our plan to realize the potential of Dyno’s CapsidMap platform for gene therapies to improve patient health.”

Under the terms of the agreement, Dyno will be responsible for using AI technology and its suite of machine learning and experimental tools for the design and discovery of novel AAV capsids, the cell-targeting protein shell of viral vectors, with improved functional properties for gene therapy. Novartis will be responsible for conducting preclinical, clinical, and commercialization activities for the gene therapy product candidates created with the novel AAV capsids. Dyno will receive upfront consideration plus committed research funding and license fees. Additionally, Dyno will be eligible to receive clinical, regulatory and sales milestone payments. Dyno will also receive royalties on worldwide net sales of any commercial products developed through the partnership.