Date: 14-Oct-2019

Goldfinch Bio Announces Licensing Agreement with Takeda for CB1 Monoclonal Antibody for the Treatment of Rare and Metabolic Kidney Diseases

Goldfinch Bio, a U.S.-based, clinical stage biotechnology company focused on discovering and developing precision medicines for the treatment of kidney diseases, today announced it entered into a license agreement with Takeda Pharmaceutical Company Limited (“Takeda”) for worldwide rights to a preclinical, peripherally-restricted cannabinoid receptor 1 (CB1) monoclonal antibody. Goldfinch Bio will assume all development and commercialization responsibilities for the treatment of rare and metabolic kidney diseases worldwide. However, the agreement grants Takeda the option, prior to the initiation of pivotal studies, to request Goldfinch Bio negotiate with Takeda for sub-licensing of Japanese rights to Takeda. Financial terms of the agreement were not disclosed. Goldfinch Bio plans to file an investigational new drug (IND) application for this CB1 inhibitor, re-named GFB-024, in the second half of 2020. “In recent years, our understanding of the role of CB1 signaling in exacerbating progressive kidney diseases has grown substantially. In this context, a monoclonal antibody directed toward the CB1 receptor is potentially well-suited to elicit the beneficial pharmacology associated with the peripheral inhibition of the CB1 receptor,” said Anthony Johnson, M.D., President and Chief Executive Officer of Goldfinch Bio. “Goldfinch Bio will deploy its biology platform and Kidney Genome AtlasTM to develop this therapeutic agent in subsets of patients with kidney diseases most likely to preferentially respond to CB1 inhibition. With GFB-887, our TRPC5 inhibitor for FSGS, in Phase 1 clinical development, this peripheral CB1 inhibitor will be the second clinic-ready program in Goldfinch Bio’s pipeline. We look forward to collaborating with Takeda on this program.”